I've noticed that having the Temperance virtue has a huge effect on your alignment just for going hungry a little. If you only eat when you're hungry, you'll quickly end up Lawful no matter what else you do. This is a little weird in and of itself, but it's a special pain for characters using an 'evil' magic school where spell failure rate is affected by alignment.
Also Giants throwing rocks!

The Knights of the Round Table are nasty too, but in a good way - they made for some interesting mid-game battles.
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