Hold Life gives you a strong saving throw against experience loss, and also greatly reduces the drain if your save fails. There is no foolproof defense against experience drain except to not let draining attacks hit you. However, having hold life makes experience drain laughably ignorable; you'll get back the lost experience very quickly.
(Nether resistance is foolproof against experience drain from nether attacks, though)
(Nether resistance is foolproof against experience drain from nether attacks, though)
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